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Published, February 18th 2003

Nickel and its compounds

On request of the Minister of Social Affairs and Employment, the Health Council of the Netherlands evaluates the effects on the reproduction of substances at the workplace. The Health Council’s Committee for Compounds Toxic to Reproduction recommends to classify compounds toxic to reproduction according to the Directive 93/21/EEC of the European Union. In the present report the committee has reviewed nickel and its compounds.

The committee’s recommendations are:

Metallic nickel

  • for effects on fertility, the committee recommends no classification of metallic nickel, due to a lack of appropriate data
  • for developmental toxicity, the committee recommends not to classify metallic nickel due to a lack of appropriate data
  • the committee is of the opinion that a lack of appropriate data precludes the labelling of metallic nickel for effects during lactation.

Nickel carbonyl

  • for effects on fertility, the committee recommends no classification of nickelcarbonyl, due to a lack of appropriate data
  • for effects on development, the committee recommends to classify nickelcarbonyl in category 3 (substances which cause concern for humans owing to possible developmental effects) and to label the compound with R63 (possible risk of harm to the unborn child)
  • the committee is of the opinion that a lack of appropriate data precludes the labelling of nickelcarbonyl for effects during lactation.

Soluble nickel salts

  • for effects on fertility, the committee recommends to classify the soluble nickel salts in category 3 (substances which cause concern for human fertility) and to label the compounds with R62 (possible risk of impaired fertility)
  • for effects on development the committee recommends to classify the soluble nickel salts in category 2 (substances which should be regarded as if they impair fertility in humans) and to label the compounds with R61 (May cause harm to the unborn child)
  • for effects during lactation, the committee recommends that the soluble nickel salts should be labelled with R64 (may cause harm to breastfed babies).

Insoluble nickel salts

  • for effects on fertility, the committee recommends no classification of the insoluble nickel salts, due to a lack of appropriate data
  • for developmental toxicity, the committee recommends not to classify the insoluble nickel salts due to a lack of appropriate data
  • the committee is of the opinion that a lack of appropriate data precludes the labelling of insoluble nickel salts for effects during lactation.

Committee

GBBS (OSH)

This publication may be cited as follows

Health Council of the Netherlands: Committee for Compounds toxic to reproduction. Nickel and its compounds; Evaluation of the effects on reproduction, recommendation for classification. The Hague: Health Council of the Netherlands, 2003; publication no. 2 ISBN 90-5549-466-6