Toxicity testing: a more efficient approach

General recommendations on the principles and procedures for assessing the toxicity of chemicals entitled ‘Toxicology-based recommended exposure limits’ were published by a Health Council Committee in 1996. The present report, drawn up by the same Committee, elaborates the programme outlined then. It concentrates on the construction of an integral toxicity profile, including the relations between various types of toxicity research.

Committee

• Dr WRF Notten, toxicologist; TNO Prevention and Health, Leiden, chair
• Dr WFJPM ten Berge, toxicologist; DSM, Heerlen
• Dr BJ Blaauboer, toxicologist; IRAS, University of Utrecht
• Prof. VJ Feron, Emeritus Professor of biological toxicology; University of Utrecht
• Prof. PHM Lohman, Professor of radiation genetics and chemical mutagenesis; University of Leiden
• Dr G de Mik, toxicologist; National Institute of Public Health and the Environment, Bilthoven
• Prof. WF Passchier, Health Council of the Netherlands, The Hague, advisor
• Dr MN Pieters, National Institute of Public Health and the Environment, Bilthoven, advisor
• Dr GMH Swaen, epidemiologist; University of Maastricht
• Dr RA Woutersen, toxicologist/pathologist; TNO Nutrition, Zeist
• Dr JA van Zorge, Ministry of Housing, Spatial Planning and the Environment, The Hague, advisor
• Dr EJ Schoten, Health Council of the Netherlands, The Hague, secretary
• Dr PW van Vliet, Health Council of the Netherlands, The Hague, secretary