Cyclic acid anhydrides; Health-based recommended occupational exposure limit

In a first step the toxicity of the compounds was evaluated. This is done in cooperation with the Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. The results of the evaluation, which are published in 2004, are included in Part II of this advisory report. In the first part, the DECOS describes the most relevant data, supplied by newly presented data, and advices on an HBR-OEL. The conclusions of the DECOS are based on scientific papers published before December 2009.

Committee

• G.J. Mulder, emeritus professor of toxicology, Leiden University, Leiden, chairman
• R.B. Beems, toxicologic pathologist, formerly employed at the National Institute for Public Health and the Environment, Bilthoven
• P.J. Boogaard, toxicologist, Shell International BV, The Hague
• J.J.A.M. Brokamp, Social and Economic Council, The Hague, advisor
• D.J.J. Heederik, professor of risk assessment in occupational epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht
• R. Houba, occupational hygienist, The Netherlands Expertise Centre for Occupational Respiratory Disorders, Utrecht
• H. van Loveren, professor of immunotoxicology, Maastricht University, Maastricht, and National Institute for Public Health and the Environment, Bilthoven
• T.M. Pal, occupational physician, Netherlands Center for Occupational Diseases, Amsterdam
• A.H. Piersma, professor of reproductive toxicology, Utrecht University, Utrecht and National Institute for Public Health and the Environment, Bilthoven
• H.P.J. te Riele, professor of molecular biology, VU University Amsterdam, Amsterdam
• I.M.C.M. Rietjens, professor of toxicology, Wageningen University and Research Centre, Wageningen
• H. Roelfzema, Ministry of Health, Welfare and Sport, The Hague, advisor
• G.M.H. Swaen, epidemiologist, Dow Benelux N.V., Terneuzen
• R.C.H. Vermeulen, Epidemiologist/environmental hygienist, Institute for Risk Assessment Sciences, Utrecht University, Utrecht
• R.A. Woutersen, Professor of translational toxicology, Wageningen University, Wageningen, and TNO Quality of Life, Zeist
• P.B. Wulp, occupational physician, Labour Inspectorate, Groningen
• J.M. Rijnkels, Health Council of the Netherlands, The Hague, scientific secretary
• A.S.A.M van der Burght, Health Council of the Netherlands, The Hague, scientific secretary

The Nordic Expert Group (NEG)

• G. Johanson, professor of occupational toxicology, Karolinska Institutet, formerly the National Institute for Working Life (Sweden), chairman
• V. Kristjansson, organic chemist, Administration of Occupational Safety and Health (Iceland)
• K. Savolainen, professor of toxicology, Finnish Institute of Occupational Health (Finland)
• V. Skaug, toxicologist, occupational physician, National Institute of Occupational health (Norway)
• K. Sørig Hougaard, toxicologist, National Research Centre for the Working Environment, formerly the Institute of Occupational Health (Denmark)
• J. Järnberg, Swedish Work Environment Authority, formerly the National Institute for Working Life (Sweden), scientific secretary